Early results suggest group most vulnerable to serious illness and death could build immunity
The discovery that the vaccine being developed triggers protective antibodies and T-cells in older age groups has encouraged researchers
A vaccine considered a frontrunner in the race to protect the global population from Covid-19 has produced a robust immune response in elderly people, the group at highest risk from the disease, according to two people familiar with the finding.
The discovery that the vaccine being developed by the University of Oxford, in collaboration with AstraZeneca, triggers protective antibodies and T-cells in older age groups has encouraged researchers as they seek evidence that it will spare those in later life from serious illness or death from the virus.
Age has emerged as the principal risk factor for a severe bout of Covid-19.
However, the immune system weakens with age, raising concerns that the very group that most needs the protection of a vaccine may generate the least effective response to one.
People aware of the results from so-called immunogenicity blood tests carried out on a subset of older participants say the findings echo data released in July that showed the vaccine generated “robust immune responses” in a group of healthy adults aged between 18 and 55.
The earlier findings showed that the vaccine induced two forms of human immune response — generating antibodies and T-cells — for at least 56 days, according to an analysis published in The Lancet.
Positive immunogenicity tests do not guarantee the vaccine will ultimately prove safe and effective in older people.
That will not be known until full trial data for the age group has been analysed.
However, researchers have been encouraged by the latest development, details of which are shortly to be published in a clinical journal.
The University of Oxford declined to comment. Coronavirus: the global race for a vaccine | FT Interview Jonathan Ball, professor of virology at the University of Nottingham, said: “If what they’ve got is data that show the vaccine generates good immunity, as measured in the lab, in the age group over 55, and that also includes good responses in people who are even older than that, I think that’s a promising sign.”
He cautioned, however, that while good immunogenicity data would be encouraging “ultimately, it’s whether the vaccine protects against serious disease that’s crucial and we will only know that from phase 3 trials”.
One person familiar with thinking in Whitehall suggested there was optimism that vaccination of priority groups such as NHS staff on the frontline of the fight against Covid-19 might be able to get under way as early as January. Recommended FT News Briefing podcast10 min listen EU member states hesitate on recovery fund loans, upbeat Oxford vaccine trials, Brexit borders However, one official played down that speedy timetable, suggesting there were considerable uncertainties, including the timing and robustness of results from phase 3 trials and whether approval could be secured from the UK regulator, the Medicines and Healthcare products Regulatory Agency.
Last Thursday Patrick Vallance, government chief scientific adviser, told a Downing Street news conference that while vaccine development was progressing well, “I remain of the view that the possibility of wider spread use of a vaccine isn’t going to be until spring of next year”.
The outcome of the trials is being closely watched around the world.
The US arm of the Oxford/AstraZeneca study was given the go-ahead to resume on Friday, having been halted since September 6 after a participant developed neurological symptoms.
Similar Recent Posts by this Author:
- WITH GUINEA PIGS THE PROBLEM IS IF YOU PICK THEM UP BY THEIR TAILS THEIR EYES DROP OUT – THIS COULD BE THE SAME WITH A COCKTAIL OF VACCINES
- VACCINES THAT DO NOT GIVE SUFFICIENT IMMUNITY TO “THIS” COVID VIRUS ARE NOT LIKELY TO BE EFFECTIVE TO MUTATIONS OF THIS VIRUS OR OTHER COVID STRAINS
- ONLY 70% OVERALL SAFE FOR THOSE UNDER 65 TO- DATE – AND THE RISK FOR THE 30% ?
- Rightsandwrongs asked the 99% trial VACCINE question – HAVE OVER 75 GUINEA PIGS WITH UNDERLYING HEALTH ISSUES BEEN TESTED ?
- CHINA HAS A PEOPLE’S NON PROFIT MAKING VACCINE – IT IS TAKING EXTREME CARE OVER
- HOSPITAL CROSS INFECTION CONTROL IS NOT “SAFE” AS CON. ANAEST. CLAIMS-FOR PATIENTS A LACK OF FILTERED PRESSURED AIR, INFECTIOUS DISEASES BEDS & ENOUGH EXPERIENCED STAFF-SO THESE DRUGS MAY TAKEN AT HOME IF FUNDED BY PRIMARY CARE & IF NOT IS A DEATH WARRANT